Article

Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS/AML

2022-09-27

Abstract excerpt

Splicing modulation is a promising treatment strategy pursued to date only in splicing-factor mutant cancers; however, its therapeutic potential is poorly understood outside of this context. Like splicing factors, genes encoding components of the cohesin complex are frequently mutated in cancer, including myelodysplastic syndromes (MDS) and secondary acute myeloid leukemia (AML), where they are associated with poo...

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Literature Corpus work: 3a0eb365-2f5f-5dcc-a492-60db625a870e
DOI: 10.1101/2022.09.26.509430

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