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Article

miR-15a-5p and miR-21-5p contribute to chemoresistance in cytogenetically normal acute myeloid leukaemia by targeting PDCD4, ARL2 and BTG2.

Journal of cellular and molecular medicine - 1 Jan 2021

Vandewalle Virginie, Essaghir Ahmed, Bollaert Emeline, Lenglez Sandrine, Graux Carlos, Schoemans Hélène, Saussoy Pascale, Michaux Lucienne, Valk Peter J M, Demoulin Jean-Baptiste, Havelange Violaine

Abstract excerpt

Cytarabine and daunorubicin are old drugs commonly used in the treatment of acute myeloid leukaemia (AML). Refractory or relapsed disease because of chemotherapy resistance is a major issue. microRNAs (miRNAs) were incriminated in resistance. This study aimed to identify miRNAs involved in chemoresistance in AML patients and to define their target genes. We focused on cytogenetically normal AML patients with...

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Share to Cytarabine
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Leukemia, Myeloid, Acute

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Share to Nucleophosmin

Share to Principal Component Analysis

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Identifiers

PMID: 33270982
DOI: 10.1111/jcmm.16110
PMCID: PMC7810923

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