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Article

Altered thymic niche synergistically drives the massive proliferation of malignant thymocytes.

eLife - 16 Sept 2025

Tsingos Erika, Dick Advaita M, Bajoghli Baubak

Abstract excerpt

The discovery of genetic alterations in patient samples over the last decades has reinforced a cell-autonomous view of proliferative expansion during T-cell acute lymphoblastic leukemia (T-ALL) development in the thymus. However, the potential contribution of non-cell-autonomous factors, particularly the impact of thymic epithelial cells (TECs) within the thymic niche during the initiation phase, remains...

Read the complete abstract on PubMed

Topics

Animals
Oryzias
Thymocytes
Cell Proliferation
Thymus Gland
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Epithelial Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Humans

Receptors, Interleukin-7

Computer Simulation

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 40955905
DOI: 10.7554/eLife.101137
PMCID: PMC12440356

Genes

IL7R
TEC

Provenance

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