Article
Risk of Breast Cancer Among Carriers of Pathogenic Variants in Breast Cancer Predisposition Genes Varies by Polygenic Risk Score.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Aug 2021
Gao Chi, Polley Eric C, Hart Steven N, Huang Hongyan, Hu Chunling, Gnanaolivu Rohan, Lilyquist Jenna, Boddicker Nicholas J, Na Jie, Ambrosone Christine B, Auer Paul L, Bernstein Leslie, Burnside Elizabeth S, Eliassen A Heather, Gaudet Mia M, Haiman Christopher, Hunter David J, Jacobs Eric J, John Esther M, Lindström Sara, Ma Huiyan, Neuhausen Susan L, Newcomb Polly A, O'Brien Katie M, Olson Janet E, Ong Irene M, Patel Alpa V, Palmer Julie R, Sandler Dale P, Tamimi Rulla, Taylor Jack A, Teras Lauren R, Trentham-Dietz Amy, Vachon Celine M, Weinberg Clarice R, Yao Song, Weitzel Jeffrey N, Goldgar David E, Domchek Susan M, Nathanson Katherine L, Couch Fergus J, Kraft Peter
Abstract excerpt
PURPOSE: This study assessed the joint association of pathogenic variants (PVs) in breast cancer (BC) predisposition genes and polygenic risk scores (PRS) with BC in the general population. METHODS: A total of 26,798 non-Hispanic white BC cases and 26,127 controls from predominately population-based studies in the Cancer Risk Estimates Related to Susceptibility consortium were evaluated for PVs in BRCA1, BRCA2,...
Topics
- Adult
- Aged
- Breast Neoplasms
- Female
- Genetic Predisposition to Disease
- Genetic Variation