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Investigation of monogenic causes of familial breast cancer: data from the BEACCON case-control study

11 Jun 2021

Abstract excerpt

Abstract Breast cancer (BC) has a significant heritable component but the genetic contribution remains unresolved in the majority of high-risk BC families. This study aims to investigate the monogenic causes underlying the familial aggregation of BC beyond BRCA1 and BRCA2 , including the identification of new predisposing genes. A total of 11,511 non-BRCA familial BC cases and population-matched cancer-free...

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PMID: 34117267
DOI: 10.1038/s41523-021-00279-9

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