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Article

Influence of the disordered domain structure of MeCP2 on its structural stability and dsDNA interaction.

International journal of biological macromolecules - 1 Apr 2021

Ortega-Alarcon David, Claveria-Gimeno Rafael, Vega Sonia, Jorge-Torres Olga C, Esteller Manel, Abian Olga, Velazquez-Campoy Adrian

Abstract excerpt

Methyl-CpG binding protein 2 (MeCP2) is a transcriptional regulator and a chromatin-associated structural protein. MeCP2 deregulation results in two neurodevelopmental disorders: MeCP2 dysfunction is associated with Rett syndrome, while excess of activity is associated with MeCP2 duplication syndrome. MeCP2 is an intrinsically disordered protein (IDP) constituted by six structural domains with variable, small...

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Identifiers

PMID: 33548325
DOI: 10.1016/j.ijbiomac.2021.01.206

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Influence of the disordered domain structure of MeCP2 on its structural stability and dsDNA interaction.PMID 33548325Read ↗

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