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Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice

5 Feb 2009

Abstract excerpt

BACKGROUND: In a transgenic mouse model of Alzheimer disease (AD), cleavage of the amyloid precursor protein (APP) by the alpha-secretase ADAM10 prevented amyloid plaque formation, and alleviated cognitive deficits. Furthermore, ADAM10 overexpression increased the cortical synaptogenesis. These results suggest that upregulation of ADAM10 in the brain has beneficial effects on AD pathology. RESULTS: To assess the...

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PMID: 19196476
DOI: 10.1186/1471-2164-10-66

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