Succinate dehydrogenase deficient gastrointestinal stromal tumor in a three month old boy with a fatal clinical course: A case report and review of literature

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Succinate dehydrogenase deficient gastrointestinal stromal tumors (SDH-deficient GISTs), which lack KIT or PDGFRA mutations demonstrate unique clinical and pathological features, and they respond poorly to standard targeted therapy. We herein present a novel case of SDH-deficient GIST in a three-month-old infant’s colon mesentery, and he is the youngest patient...

Topics

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• DNA Mutational Analysis
• Gastrointestinal Stromal Tumors
• Germ-Line Mutation
• Infant
• Mutation
• Proto-Oncogene Proteins c-kit
• Receptor, Platelet-Derived Growth Factor alpha
• Succinate Dehydrogenase

Identifiers and source

Literature Corpus work

69861910-66f6-5654-be49-13d9017c6e2b

DOI

10.21203/rs.3.rs-69380/v2