Article
Current management of succinate dehydrogenase-deficient gastrointestinal stromal tumors.
Cancer metastasis reviews - 1 Sept 2019
Neppala Pushpa, Banerjee Sudeep, Fanta Paul T, Yerba Mayra, Porras Kevin A, Burgoyne Adam M, Sicklick Jason K
Abstract excerpt
Gastrointestinal stromal tumors (GISTs) are increasingly recognized as having diverse biology. With the development of tyrosine kinase inhibitors molecularly matched to oncogenic KIT and PDGFRA mutations, GISTs have become a quintessential model for precision oncology. However, about 5-10% of GIST lack these driver mutations and are deficient in succinate dehydrogenase (SDH), an enzyme that converts succinate to...
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