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Article

Succinate dehydrogenase deficient gastrointestinal stromal tumors (GISTs) - a review.

The international journal of biochemistry & cell biology - 1 Aug 2014

Miettinen Markku, Lasota Jerzy

Abstract excerpt

Loss of function of the succinate dehydrogenase complex characterizes a rare group of human tumors including some gastrointestinal stromal tumors, paragangliomas, renal carcinomas, and pituitary adenomas, and these can all be characterized as SDH-deficient tumors. Approximately 7.5% of gastric gastrointestinal stromal tumors are SDH-deficient and not driven by KIT/PDGFRA mutations, as are most other GISTs. The...

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Source

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Identifiers

PMID: 24886695
DOI: 10.1016/j.biocel.2014.05.033
PMCID: PMC4112081

Genes

SDHA
KIT
PDGFRA
SDHB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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