Succinate dehydrogenase deficiency in pediatric and adult gastrointestinal stromal tumors

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) in adults are generally driven by somatic gain-of-function mutations in KIT or PDGFRA, and biological therapies targeted to these receptor tyrosine kinases comprise part of the treatment regimen for metastatic and inoperable GISTs. A minority (10-15%) of GISTs in adults, along with ∼85% of pediatric GISTs, lacks oncogenic mutations in KIT and PDGFRA. Not surprisingly these...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Gastrointestinal Tumor Research and Treatment
• Share to Neurofibromatosis and Schwannoma Cases
• Share to Sarcoma Diagnosis and Treatment