Article

Keratinocyte desmoglein 1 regulates the epidermal microenvironment and tanning response

2018-09-20

Abstract excerpt

<h4>ABSTRACT</h4> Coordinated responses to environmental stimuli within the keratinocyte:melanocyte niche are poorly understood. Desmoglein 1 (Dsg1), a keratinocyte-specific desmosomal cell-cell adhesion protein with emerging signaling roles, is reduced by ultraviolet light radiation. Loss-of-function Dsg1 mutations elevate keratinocyte cytokines in Severe dermatitis, multiple Allergies, and Metabolic wasting (SA...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 69811ad0-a6e8-57d3-9ecf-1b31834301a7
DOI: 10.1101/423269

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Keratinocyte desmoglein 1 regulates the epidermal microenvironment and tanning responseDOI 10.1101/423269Read

Keratinocyte cadherin desmoglein 1 controls melanocyte behavior through paracrine signalingSemantic proximity Read

Crosstalk in skin: Loss of desmoglein 1 in keratinocytes inhibits BRAF <sup>V600E</sup> -induced cellular senescence in human melanocytesSemantic proximity Read

Dangerous liaisons: Loss of keratinocyte control over melanocytes in melanomagenesis.Semantic proximity Read

Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting.Semantic proximity Read

UV signaling pathways within the skin.Semantic proximity Read

Participation of keratinocyte‐ and fibroblast‐derived factors in melanocyte homeostasis, the response to UV, and pigmentary disordersSemantic proximity Read

Sexual dimorphism in melanocyte stem cell behavior reveals combinational therapeutic strategies for cutaneous repigmentationSemantic proximity Read

SASH1 impairs melanin synthesis and metastasis by down-regulating the TGF-β signaling pathwaySemantic proximity Read

Crosstalk in skin: melanocytes, keratinocytes, stem cells, and melanomaSemantic proximity Read

CCN3 controls 3D spatial localization of melanocytes in the human skin through DDR1Semantic proximity Read

Th17-skewed inflammation due to genetic deficiency of a cadherin stress sensorSemantic proximity Read

Regulation of melanocyte stem cells in the pigmentation of skin and its appendages: Biological patterning and therapeutic potentialsSemantic proximity Read