Participation of keratinocyte‐ and fibroblast‐derived factors in melanocyte homeostasis, the response to UV, and pigmentary disorders

Abstract excerpt

Human epidermal melanocytes play a central role in sensing the environment and protecting the skin from the drastic effects of solar ultraviolet radiation and other environmental toxins or inflammatory agents. Melanocytes survive in the epidermis for decades, which subjects them to chronic environmental insults. Melanocytes have a poor self-renewal capacity; therefore, it is critical to ensure their survival with...