Article
Cell-type-specific meQTLs extend melanoma GWAS annotation beyond eQTLs and inform melanocyte gene-regulatory mechanisms.
American journal of human genetics - 2 Sept 2021
Zhang Tongwu, Choi Jiyeon, Dilshat Ramile, Einarsdóttir Berglind Ósk, Kovacs Michael A, Xu Mai, Malasky Michael, Chowdhury Salma, Jones Kristine, Bishop D Timothy, Goldstein Alisa M, Iles Mark M, Landi Maria Teresa, Law Matthew H, Shi Jianxin, Steingrímsson Eiríkur, Brown Kevin M
Abstract excerpt
Although expression quantitative trait loci (eQTLs) have been powerful in identifying susceptibility genes from genome-wide association study (GWAS) findings, most trait-associated loci are not explained by eQTLs alone. Alternative QTLs, including DNA methylation QTLs (meQTLs), are emerging, but cell-type-specific meQTLs using cells of disease origin have been lacking. Here, we established an meQTL dataset by...
Topics
- Alleles
- Atlases as Topic
- Chromatin
- Chromosome Mapping
- DNA Methylation
- Gene Expression Regulation
- Gene Regulatory Networks
- Genetic Predisposition to Disease
- Genome, Human