Article

A platform for case-control matching enables association studies without genotype sharing

2018-11-14

Abstract excerpt

Acquiring a sufficiently powered cohort of control samples can be time consuming or, sometimes, impossible. Accordingly, an ability to leverage control samples that were already collected and sequenced elsewhere could dramatically improve power in all genetic association studies. However, since majority of the genotyped and sequenced human DNA samples to date are subject to strict data sharing regulations, large-s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 697bb013-b4d6-58bd-8ce2-bfbd16b8d976
DOI: 10.1101/470450

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 11 closest

A platform for case-control matching enables association studies without genotype sharingDOI 10.1101/470450Read

Public platform with 39,472 exome control samples enables association studies without genotype sharing.Semantic proximity Read

Opportunities and challenges for the use of common controls in sequencing studies.Semantic proximity Read

Using ancestry matching to combine family-based and unrelated samples for genome-wide association studies.Semantic proximity Read

Genotype-based matching to correct for population stratification in large-scale case-control genetic association studies.Semantic proximity Read

Association analysis using next-generation sequence data from publicly available control groups: the robust variance score statistic.Semantic proximity Read

Using public control genotype data to increase power and decrease cost of case-control genetic association studies.Semantic proximity Read

On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants.Semantic proximity Read

A method to exploit the structure of genetic ancestry space to enhance case-control studiesSemantic proximity Read

A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies.Semantic proximity Read

Using previously genotyped controls in genome-wide association studies (GWAS): application to the Stroke Genetics Network (SiGN)Semantic proximity Read

Including additional controls from public databases improves the power of a genome-wide association study.Semantic proximity Read