Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Public platform with 39,472 exome control samples enables association studies without genotype sharing.

Nature genetics - 1 Feb 2024

Artomov Mykyta, Loboda Alexander A, Artyomov Maxim N, Daly Mark J

Abstract excerpt

Acquiring a sufficiently powered cohort of control samples matched to a case sample can be time-consuming or, in some cases, impossible. Accordingly, an ability to leverage genetic data from control samples that were already collected elsewhere could dramatically improve power in genetic association studies. Sharing of control samples can pose significant challenges, since most human genetic data are subject to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to Exome
Share to Genetic Association Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Source

Open in PubMed Open full text

Identifiers

PMID: 38200129
DOI: 10.1038/s41588-023-01637-y
PMCID: PMC10864173

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Public platform with 39,472 exome control samples enables association studies without genotype sharing.PMID 38200129Read ↗

A platform for case-control matching enables association studies without genotype sharingSemantic proximity Read ↗

Opportunities and challenges for the use of common controls in sequencing studies.Semantic proximity Read ↗

Case-only exome sequencing and complex disease susceptibility gene discovery: study design considerations.Semantic proximity Read ↗

Expanding the pool of public controls for GWAS via a method for combining genotypes from arrays and sequencingSemantic proximity Read ↗

A Collection of 2,280 Public Domain (CC0) Curated Human GenotypesSemantic proximity Read ↗

Association analysis using next-generation sequence data from publicly available control groups: the robust variance score statistic.Semantic proximity Read ↗

Weighted pooling--practical and cost-effective techniques for pooled high-throughput sequencing.Semantic proximity Read ↗

ProxECAT: Proxy External Controls Association Test. A new case-control gene region association test using allele frequencies from public controlsSemantic proximity Read ↗

Using public control genotype data to increase power and decrease cost of case-control genetic association studies.Semantic proximity Read ↗

Illumina human exome genotyping array clustering and quality control.Semantic proximity Read ↗

Identifying rare variants with optimal depth of coverage and cost-effective overlapping pool sequencing.Semantic proximity Read ↗

Quality Control for the Illumina HumanExome BeadChip.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.