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Article

Association analysis using next-generation sequence data from publicly available control groups: the robust variance score statistic.

Bioinformatics (Oxford, England) - 1 Aug 2014

Derkach Andriy, Chiang Theodore, Gong Jiafen, Addis Laura, Dobbins Sara, Tomlinson Ian, Houlston Richard, Pal Deb K, Strug Lisa J

Abstract excerpt

MOTIVATION: Sufficiently powered case-control studies with next-generation sequence (NGS) data remain prohibitively expensive for many investigators. If feasible, a more efficient strategy would be to include publicly available sequenced controls. However, these studies can be confounded by differences in sequencing platform; alignment, single nucleotide polymorphism and variant calling algorithms; read depth;...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24733292
DOI: 10.1093/bioinformatics/btu196
PMCID: PMC4103600

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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