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Article

On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants.

American journal of human genetics - 1 Feb 2008

Luca Diana, Ringquist Steven, Klei Lambertus, Lee Ann B, Gieger Christian, Wichmann H-Erich, Schreiber Stefan, Krawczak Michael, Lu Ying, Styche Alexis, Devlin Bernie, Roeder Kathryn, Trucco Massimo

Abstract excerpt

Resources being amassed for genome-wide association (GWA) studies include "control databases" genotyped with a large-scale SNP array. How to use these databases effectively is an open question. We develop a method to match, by genetic ancestry, controls to affected individuals (cases). The impact of this method, especially for heterogeneous human populations, is to reduce the false-positive rate, inflate other...

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Identifiers

PMID: 18252225
DOI: 10.1016/j.ajhg.2007.11.003
PMCID: PMC2427172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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