Article

Identification of Aorta-Specific DNA Methylation Patterns in Cell-Free DNA from Patients with Bicuspid Aortic Valve-Associated Aortopathy and Correlation with Aortic Wall Cell Death

2020-12-21

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> In a proof-of-concept study we sought to identify aorta-specific differentially methylated regions (DMRs) detectable in plasma cell-free DNA (cfDNA) obtained from patients with bicuspid aortic valve (BAV)-associated aortopathy. <h4>Methods</h4> We used bioinformatics and publicly-available human methylomes to identify aorta-specific DMRs. We used data from 4D-flow cardiac ma...

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Literature Corpus work: 697b6f55-925f-531a-ade0-6d1af9c73b2f
DOI: 10.1101/2020.12.20.423686

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