Article

Aorta-on-a-chip reveals impaired mitochondrial dynamics as a therapeutic target for aortic aneurysm in bicuspid aortic valve disease

2021-07-09

Abstract excerpt

<h4>Background</h4> Bicuspid aortic valve (BAV) is the most common congenital cardiovascular disease in general population and is frequently associated with the development of thoracic aortic aneurysm (TAA). There is no effective strategy to intervene with TAA progression due to an incomplete understanding of the pathogenesis. Insufficiency of NOTCH1 expression is highly related to BAV-TAA, but the underlying mec...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a41e0726-0465-58ec-af1c-a3892f55dc02
DOI: 10.1101/2021.07.07.21260132

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Aorta-on-a-chip reveals impaired mitochondrial dynamics as a therapeutic target for aortic aneurysm in bicuspid aortic valve diseaseDOI 10.1101/2021.07.07.21260132Read

Mitochondrial Dysfunction: A New Hallmark in Hereditable Thoracic Aortic Aneurysm DevelopmentSemantic proximity Read

Single-Cell Transcriptome Analysis Reveals Dynamic Cell Populations and Differential Gene Expression Patterns in Control and Aneurysmal Human Aortic TissueSemantic proximity Read

Molecular diagnoses and treatments--past, present, or future?Semantic proximity Read

NUAK1 regulates contraction in vascular smooth muscle cells derived from abdominal aortic aneurysm patientsSemantic proximity Read

Single-cell RNA sequencing reveals the vascular smooth muscle cell phenotypic landscape in aortic aneurysm.Semantic proximity Read

Comparative analysis of thoracic and abdominal aortic aneurysms across the segment and species at the single-cell levelSemantic proximity Read

Identification and Experimental Validation of NETosis-Mediated Abdominal Aortic Aneurysm Gene Signature Using Multi-omics, Machine Learning, and Mendelian RandomizationSemantic proximity Read

A predictive insight into the ATRNL1-mediated ceRNA network driving abdominal aortic aneurysm progression via VSMC phenotypic switching.Semantic proximity Read

Genetic Bases of Bicuspid Aortic Valve: The Contribution of Traditional and High-Throughput Sequencing Approaches on Research and DiagnosisSemantic proximity Read

Multi-Omics Approaches to Define Calcific Aortic Valve Disease Pathogenesis.Semantic proximity Read

Multi-Omics Profiling in Marfan Syndrome: Further Insights into the Molecular Mechanisms Involved in Aortic DiseaseSemantic proximity Read

Unveiling cellular and molecular aspects of ascending thoracic aortic aneurysms and dissections.Semantic proximity Read