Article

Establishment and characterization of patient-derived xenograft from leptomeningeal spread of a rare pediatric anaplastic pleomorphic xanthoastrocytoma (PXA) bearing a CDC42SE2-BRAF fusion

2022-09-20

Abstract excerpt

Pleomorphic xanthoastrocytoma (PXA) is a rare subset of primary pediatric glioma with 70% 5-year disease free survival. However, up to 20% of cases present with local recurrence and malignant transformation into more aggressive type anaplastic PXA (AXPA) or glioblastoma. The understanding of disease etiology and mechanisms driving PXA and APXA are limited, and there is no standard of care. Therefore, development o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 69522b24-31d5-5c26-a0d3-29f7da3f8faa
DOI: 10.21203/rs.3.rs-2026518/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Establishment and characterization of patient-derived xenograft from leptomeningeal spread of a rare pediatric anaplastic pleomorphic xanthoastrocytoma (PXA) bearing a CDC42SE2-BRAF fusionDOI 10.21203/rs.3.rs-2026518/v1Read

Establishment and characterization of patient-derived xenograft of a rare pediatric anaplastic pleomorphic xanthoastrocytoma (PXA) bearing a CDC42SE2-BRAF fusion.Semantic proximity Read

A novel, potentially targetable TMEM106B-BRAF fusion in pleomorphic xanthoastrocytoma.Semantic proximity Read

BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications.Semantic proximity Read

A living pediatric brain tumor atlas reveals histomolecular diversity and therapeutic vulnerabilities for precision neuro-oncologySemantic proximity Read

BRAF/MEK Dual Inhibitors Therapy in Progressive and Anaplastic Pleomorphic Xanthoastrocytoma: Case Series and Literature Review.Semantic proximity Read

The evolution of pleomorphic xanthoastrocytoma: from genesis to molecular alterations and mimics.Semantic proximity Read

Multi-omic landscape of human gliomas from diagnosis to treatment and recurrenceSemantic proximity Read

Impact of WHO 2016 update of brain tumor classification, molecular markers and clinical outcomes in pleomorphic xanthoastrocytoma.Semantic proximity Read

Exomic Sequencing of Four Rare Central Nervous System Tumor TypesSemantic proximity Read

Targeted Next-Generation Sequencing Reveals Divergent Clonal Evolution in Components of Composite Pleomorphic Xanthoastrocytoma-Ganglioglioma.Semantic proximity Read

Patient-Derived Orthotopic Xenografts and Cell Lines from Pediatric High-Grade Glioma Recapitulate the Heterogeneity of Histopathology, Molecular Signatures, and Drug ResponseSemantic proximity Read

Pediatric Patient-Derived-Xenograft development in MAPPYACTS – international pediatric cancer precision medicine trial in relapsed and refractory tumorsSemantic proximity Read