Article
BRAF/MEK Dual Inhibitors Therapy in Progressive and Anaplastic Pleomorphic Xanthoastrocytoma: Case Series and Literature Review.
Journal of the National Comprehensive Cancer Network : JNCCN - 1 Nov 2022
Kata Karolina, Rodriguez-Quintero Juan C, Arevalo Octavio D, Zhang Jackie J, Bhattacharjee Meenakshi Bidwai, Ware Cornelius, Dono Antonio, Riascos-Castaneda Roy, Tandon Nitin, Blanco Angel, Esquenazi Yoshua, Ballester Leomar Y, Amsbaugh Mark, Day Arthur L, Zhu Jay-Jiguang
Abstract excerpt
Recurrent and anaplastic pleomorphic xanthoastrocytoma (r&aPXA) is a rare primary brain tumor that is challenging to treat. Two-thirds of PXA tumors harbor a BRAF gene mutation. BRAF inhibitors have been shown to improve tumor control. However, resistance to BRAF inhibition develops in most cases. Concurrent therapy with MEK inhibitors may improve tumor control and patient survival. In this study, we identified 5...
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