Article
Establishment and characterization of patient-derived xenograft of a rare pediatric anaplastic pleomorphic xanthoastrocytoma (PXA) bearing a CDC42SE2-BRAF fusion.
Scientific reports - 6 Jun 2023
Damayanti Nur P, Saadatzadeh M Reza, Dobrota Erika, Ordaz Josue D, Bailey Barbara J, Pandya Pankita H, Bijangi-Vishehsaraei Khadijeh, Shannon Harlan E, Alfonso Anthony, Coy Kathy, Trowbridge Melissa, Sinn Anthony L, Zhang Zhong-Yin, Gallagher Rosa I, Wulfkuhle Julia, Petricoin Emanuel, Richardson Angela M, Marshall Mark S, Lion Alex, Ferguson Michael J, Balsara Karl E, Pollok Karen E
Abstract excerpt
Pleomorphic xanthoastrocytoma (PXA) is a rare subset of primary pediatric glioma with 70% 5-year disease free survival. However, up to 20% of cases present with local recurrence and malignant transformation into more aggressive type anaplastic PXA (AXPA) or glioblastoma. The understanding of disease etiology and mechanisms driving PXA and APXA are limited, and there is no standard of care. Therefore, development...
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