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Single-cell atlas of multilineage cardiac organoids derived from human induced pluripotent stem cells

14 Jun 2022

Abstract excerpt

Abstract Human induced pluripotent stem cell (hiPSC)-derived cardiac organoids can be used to model human heart development and cardiovascular disease, and provide therapeutic cells to repair the heart. We used single-cell transcriptome analysis to dissect the development of 3D mini-cardiac organoids (MCOs) consisting of hiPSC-derived cardiomyocytes, and endothelial and smooth muscle cells. We found that the 3D...

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PMID: 39871934
DOI: 10.1093/lifemedi/lnac002

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