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Article

UBE2E3 sustains PRC1.1 function and leukemic stemness in acute myeloid leukemia

2026-08-25

Abstract excerpt

<title>Abstract</title> <p>Non-canonical Polycomb repressive complex 1 (ncPRC1) sustains leukemic stem cells and disease propagation in acute myeloid leukemia (AML), yet how its activity is preserved remains poorly understood. UBE2E3 is an E2 ubiquitin-conjugating enzyme and AML dependency of undefined function. Using proximity-dependent biotinylation and mass spectrometry, we identified UBE2E3 as a proximal inte...

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Literature Corpus work
db3ed09e-c65b-5bb1-81ca-32f9e4cab016
DOI
10.21203/rs.3.rs-10704032/v1
Open publication

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UBE2E3 sustains PRC1.1 function and leukemic stemness in acute myeloid leukemiaDOI 10.21203/rs.3.rs-10704032/v1
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