Article
YAP-dependent autophagy is controlled by AMPK, SIRT1 and flow intensity in kidney epithelial cells
2023-01-09
Abstract excerpt
Shear stress generated by the urinary fluid flow is an important regulator of renal function. Its dysregulation is observed in various chronic and acute kidney diseases. Previously, we demonstrated that primary cilium-dependent autophagy allows kidney epithelial cells to adapt their metabolism in response to fluid flow. Here, we show that nuclear YAP/TAZ negatively regulates autophagy machinery in kidney epithelia...
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Identifiers and source
- Literature Corpus work
- 6913c68c-1854-565e-93d7-9da5e0c8633e
- DOI
- 10.1101/2023.01.09.523237