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Article

Forkhead box O3 (FoxO3) regulates kidney tubular autophagy following urinary tract obstruction.

The Journal of biological chemistry - 18 Aug 2017

Li Ling, Zviti Ronald, Ha Catherine, Wang Zhao V, Hill Joseph A, Lin Fangming

Abstract excerpt

Autophagy has been shown to be important for normal homeostasis and adaptation to stress in the kidney. Yet, the molecular mechanisms regulating renal epithelial autophagy are not fully understood. Here, we explored the role of the stress-responsive transcription factor forkhead box O3 (FoxO3) in mediating injury-induced proximal tubular autophagy in mice with unilateral ureteral obstruction (UUO). We show that...

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Source

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Identifiers

PMID: 28705935
DOI: 10.1074/jbc.M117.791483
PMCID: PMC5566530

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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