Article

CD62L as target receptor for specific gene delivery into less differentiated human T lymphocytes

2022-09-27

Abstract excerpt

Chimeric antigen receptor (CAR) expressing T cells are a complex and heterogeneous gene therapy product with variable phenotype composition. A higher proportion of less differentiated CAR T cells is usually associated with improved antitumoral function and persistence. We describe here a novel receptor-targeted lentiviral vector (LV), named 62L-LV, that preferentially transduces less differentiated T cells marked...

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Literature Corpus work: 68fad53b-3754-5f44-be56-9b0bd5567569
DOI: 10.22541/au.166429989.90389382/v1

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