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Disrupted cerebellar structural connectome in spinocerebellar ataxia type 3 and its association with transcriptional profiles

23 May 2024

Abstract excerpt

Spinocerebellar ataxia type 3 (SCA3) is primarily characterized by progressive cerebellar degeneration, including gray matter atrophy and disrupted anatomical and functional connectivity. The alterations of cerebellar white matter structural network in SCA3 and the underlying neurobiological mechanism remain unknown. Using a cohort of 20 patients with SCA3 and 20 healthy controls, we constructed cerebellar...

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PMID: 38850215
DOI: 10.1093/cercor/bhae238

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