Article

The zinc-binding motif in tankyrases is required for the structural integrity and proper function of the catalytic domain

2021-10-04

Abstract excerpt

Tankyrases are ADP-ribosylating enzymes that regulate many physiological processes in the cell and they are therefore possible drug targets for cancer and fibrotic diseases. The catalytic ADP-ribosyl-transferase domain of tankyrases contains a unique zinc-binding motif of unknown function. Recently, this motif was suggested to be involved in the catalytic activity of tankyrases. In this work, we set out to study t...

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Identifiers and source

Literature Corpus work: 68eb3628-9a1c-5c5b-a116-f117808a73d8
DOI: 10.1101/2021.10.04.463032

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