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Novel Binding Mode of a Potent and Selective Tankyrase Inhibitor

16 Mar 2012

Abstract excerpt

Tankyrases (TNKS1 and TNKS2) are key regulators of cellular processes such as telomere pathway and Wnt signaling. IWRs (inhibitors of Wnt response) have recently been identified as potent and selective inhibitors of tankyrases. However, it is not clear how these IWRs interact with tankyrases. Here we report the crystal structure of the catalytic domain of human TNKS1 in complex with IWR2, which reveals a novel...

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PMID: 22438990
DOI: 10.1371/journal.pone.0033740

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Novel Binding Mode of a Potent and Selective Tankyrase InhibitorPMID 22438990Read ↗

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