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Assessment of TANK-binding kinase 1 as a therapeutic target in cancer

7 Dec 2017

Abstract excerpt

TANK-binding kinase 1 (TBK1) is central to multiple biological processes that promote tumorigenesis including cell division, autophagy, innate immune response and AKT-pro survival signaling. TBK1 is well studied and most known for its function in innate immunity. However, the serine threonine protein kinase received significant attention as a synthetic lethal partner and effector of the major oncogene, RAS. This...

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PMID: 29218456
DOI: 10.1007/s12079-017-0438-y

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