Article
Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1.
Journal of medicinal chemistry - 25 Jan 2018
Crew Andrew P, Raina Kanak, Dong Hanqing, Qian Yimin, Wang Jing, Vigil Dominico, Serebrenik Yevgeniy V, Hamman Brian D, Morgan Alicia, Ferraro Caterina, Siu Kam, Neklesa Taavi K, Winkler James D, Coleman Kevin G, Crews Craig M
Abstract excerpt
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that recruit an E3 ligase to a target protein to facilitate ubiquitination and subsequent degradation of that protein. While the field of targeted degraders is still relatively young, the potential for this modality to become a differentiated and therapeutic reality is strong, such that both academic and pharmaceutical institutions are now...
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