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Article

Fragment-based screening identifies molecules targeting the substrate-binding ankyrin repeat domains of tankyrase.

Scientific reports - 13 Dec 2019

Pollock Katie, Liu Manjuan, Zaleska Mariola, Meniconi Mirco, Pfuhl Mark, Collins Ian, Guettler Sebastian

Abstract excerpt

The PARP enzyme and scaffolding protein tankyrase (TNKS, TNKS2) uses its ankyrin repeat clusters (ARCs) to bind a wide range of proteins and thereby controls diverse cellular functions. A number of these are implicated in cancer-relevant processes, including Wnt/β-catenin signalling, Hippo signalling and telomere maintenance. The ARCs recognise a conserved tankyrase-binding peptide motif (TBM). All currently...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31836723
DOI: 10.1038/s41598-019-55240-5
PMCID: PMC6911004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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