Article

Immunogenomic profiling of lung adenocarcinoma reveals high-grade growth patterns are associated with an immunogenic tumor microenvironment

2022-03-18

Abstract excerpt

Lung cancer is the leading cause of cancer-related mortality in the United States. Lung adenocarcinoma (LUAD) is the most common subtype and the most epidemiologically and genetically heterogeneous. Pathologists have routinely observed phenotypic heterogeneity among LUAD primary tumors as reflected by distinct patterns of tumor growth. However, despite prior implications on the association of immune-genomic enviro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 68ae796e-895f-5857-a8b5-a945d1892655
DOI: 10.1101/2022.03.17.22272385

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immunogenomic profiling of lung adenocarcinoma reveals high-grade growth patterns are associated with an immunogenic tumor microenvironmentDOI 10.1101/2022.03.17.22272385Read

Spatial transcriptomics uncovers immune-cell plasticity and dedifferentiation signatures in aggressive lung adenocarcinoma subtypesSemantic proximity Read

Identification and validation of tumor environment phenotypes in lung adenocarcinoma by integrative genome-scale analysis.Semantic proximity Read

Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and ProgressionSemantic proximity Read

Integrative multi-omics profiling deciphers tumor microenvironment heterogeneity and immunotherapy vulnerabilities in lung neuroendocrine carcinomas.Semantic proximity Read

Up-regulated tumor intrinsic growth potential and decreased immune function orchestrate the evolution of lung adenocarcinomaSemantic proximity Read

Characterizing the Dynamics of the Single Cell Tumor Microenvironment and Immune Cell Subpopulations during the Progression of Lung AdenocarcinomaSemantic proximity Read

Tumor microenvironment and drug resistance in lung adenocarcinoma: molecular mechanisms, prognostic implications, and therapeutic strategiesSemantic proximity Read

The tumor environment immune phenotype of LUSC by genome-wide analysis.Semantic proximity Read

Lung adenocarcinoma WHO histological classes contain distinct immune cell profilesSemantic proximity Read

Archetype analysis of lung adenocarcinoma premalignancy links heterogeneity in premalignant lesions to diverging features of invasive diseaseSemantic proximity Read

Multi-omics Data Analyses Construct TME and Identify the Immune-Related Prognosis Signatures in Human LUADSemantic proximity Read

Novel Spatial Approaches to Dissect the Lung Cancer Immune MicroenvironmentSemantic proximity Read