Article

Characterising Type I Collagen Architecture in Human Bone and Osteosarcoma with Second Harmonic Generation Microscopy

2025-07-27

Abstract excerpt

Aberrant collagen matrix production is a hallmark of many cancers, including osteosarcoma (OS), the most common primary cancer of bone which remains poorly diagnosed. Here, the phenotyping potential of second harmonic generation (SHG) microscopy has been demonstrated through label-free imaging of pathologically altered collagen matrices within clinical biopsies. This work examined SHG imaging in quantifying OS-spe...

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Identifiers and source

Literature Corpus work: 689438bc-5a76-568c-9c71-85934e1fb42b
DOI: 10.1101/2025.07.23.666332

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