Article

Machine learning-assisted SHG morphometry reveals distinct collagen microarchitectures of trabecular bone and fibrosis in bone marrow biopsies

2026-07-22

Abstract excerpt

<title>Abstract</title> <p>Collagen microarchitecture in bone marrow biopsies represents a largely underexplored source of quantitative biomarkers for histopathological diagnostics and analysis of tissue remodeling. While second harmonic generation (SHG) microscopy has been increasingly applied to fibrosis assessment, the collagen organization of trabecular bone in bone marrow trephine biopsies remains poorly cha...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2d6d5f82-969d-5dc6-964d-81f75c1e23b3
DOI: 10.21203/rs.3.rs-10432021/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Machine learning-assisted SHG morphometry reveals distinct collagen microarchitectures of trabecular bone and fibrosis in bone marrow biopsiesDOI 10.21203/rs.3.rs-10432021/v1Read

Quantitative assessment of collagen architecture from routine histopathological images shows concordance with Second Harmonic Generation microscopySemantic proximity Read

Characterising Type I Collagen Architecture in Human Bone and Osteosarcoma with Second Harmonic Generation MicroscopySemantic proximity Read

Quantification of collagen and associated features from H&E-stained whole slide pathology images across cancer types using a physics-based deep learning modelSemantic proximity Read

A deep learning-based framework for standardized analysis of trabecular bone compartments from micro-CT imaging data in the mouse tibiaSemantic proximity Read

Correlative SHG-AFM imaging workflow for label-free quantitative analysis of collagen structure–function relationshipsSemantic proximity Read

Large-scale segmentation model facilitates intraoperative histopathology by third harmonic generation microscopySemantic proximity Read

Next-Generation Morphometry for pathomics-data mining in histopathologySemantic proximity Read

Automated Bone Marrow Cellularity Estimation from Whole-Slide Images Using Deep Learning: Validation in an Indian Clinical CohortSemantic proximity Read

Label-free imaging of collagen fibers in tissue slices using phase imaging with computational specificitySemantic proximity Read

Machine learning-enabled cancer diagnostics with widefield polarimetric second-harmonic generation microscopySemantic proximity Read

Artificial intelligence workflow quantifying muscle features on Hematoxylin-Eosin stained sections reveals dystrophic phenotype amelioration upon treatment.Semantic proximity Read

Machine learning assisted mid-infrared spectrochemical fibrillar collagen imaging in clinical tissuesSemantic proximity Read