Article

Glucocerebrosidase deficiency leads to neuropathology via cellular immune activation

2023-12-13

Abstract excerpt

Mutations in GBA ( glucosylceramidase beta ), which encodes the lysosomal enzyme glucocerebrosidase (GCase), are the strongest genetic risk factor for the neurodegenerative disorders Parkinson’s disease (PD) and Lewy body dementia. Recent work has suggested that neuroinflammation may be an important factor in the risk conferred by GBA mutations. We therefore systematically tested the contributions of immune-rel...

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Literature Corpus work: 68813686-f695-5dd5-a12f-1cf1c1ceae4b
DOI: 10.1101/2023.12.13.571406

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