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Article

Mitonuclear genotype remodels the metabolic and microenvironmental landscape of Hürthle cell carcinoma.

Science advances - 24 Jun 2022

Ganly Ian, Liu Eric Minwei, Kuo Fengshen, Makarov Vladimir, Dong Yiyu, Park Jinsung, Gong Yongxing, Gorelick Alexander N, Knauf Jeffrey A, Benedetti Elisa, Tait-Mulder Jacqueline, Morris Luc G T, Fagin James A, Intlekofer Andrew M, Krumsiek Jan, Gammage Payam A, Ghossein Ronald, Xu Bin, Chan Timothy A, Reznik Ed

Abstract excerpt

Hürthle cell carcinomas (HCCs) display two exceptional genotypes: near-homoplasmic mutation of mitochondrial DNA (mtDNA) and genome-wide loss of heterozygosity (gLOH). To understand the phenotypic consequences of these genetic alterations, we analyzed genomic, metabolomic, and immunophenotypic data of HCC and other thyroid cancers. Both mtDNA mutations and profound depletion of citrate pools are common in HCC and...

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Share to Cancer, Hypoxia, and Metabolism
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35731870
DOI: 10.1126/sciadv.abn9699
PMCID: PMC9216518

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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