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Article

Cis-acting polymorphisms affect complex traits through modifications of microRNA regulation pathways.

PloS one - 1 Jan 2012

Arnold Matthias, Ellwanger Daniel C, Hartsperger Mara L, Pfeufer Arne, Stümpflen Volker

Abstract excerpt

Genome-wide association studies (GWAS) have become an effective tool to map genes and regions contributing to multifactorial human diseases and traits. A comparably small number of variants identified by GWAS are known to have a direct effect on protein structure whereas the majority of variants is thought to exert their moderate influences on the phenotype through regulatory changes in mRNA expression. MicroRNAs...

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Identifiers

PMID: 22606281
DOI: 10.1371/journal.pone.0036694
PMCID: PMC3350471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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