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Article

RNAi screen identifies KIF15 as a novel regulator of integrin endocytic trafficking

1 Jan 2014

Abstract excerpt

α2β1 integrin is one of the most important collagen-binding receptors, and it has been implicated in numerous thrombotic and immune diseases. α2β1 integrin is a potent tumour suppressor, and its downregulation is associated with increased metastasis and poor prognosis in breast cancer. Currently, very little is known about the mechanism that regulates the cell-surface expression and trafficking of α2β1 integrin....

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PMID: 24659801
DOI: 10.1242/jcs.137281

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