Article

A cryptic tubulin-binding domain links MEKK1 to microtubule remodelling

2020-04-08

Abstract excerpt

<h4>ABSTRACT</h4> The MEKK1 protein is a pivotal kinase activator of responses to cellular stress. Activation of MEKK1 can trigger various responses, including mitogen activated protein (MAP) kinases, NF-κB signalling, or cell migration. Notably, MEKK1 activity is triggered by microtubule-targeting chemotherapies, amongst other stressors. Here we show that MEKK1 contains a previously unidentified tumour overexpre...

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Literature Corpus work: 197498bb-143e-5523-8541-02bc2192bd2d
DOI: 10.1101/2020.04.07.030676

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