Article

Heparanase 2 regulates endothelial permeability and prevents from proteinuria via VEGFA and FGF signaling

2024-08-20

Abstract excerpt

<h4>Background</h4> Heparan sulfates (HS) attached to the apical surface of vascular endothelial cells (ECs) play an important role in regulating endothelial permeability and ligand recognition by cell-surface receptors. Shedding of heparan sulfate (HS) from the EC surface increases vascular leakage and is associated with vascular diseases. Recently, heparanase 2 (Hpa2) was described as a novel regulatory molecul...

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Literature Corpus work: 682c2c6b-b6a3-5c9c-b60e-104056cf7592
DOI: 10.1101/2024.08.14.608012

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