Article
Glycome and transcriptome regulation of vasculogenesis.
Circulation - 10 Nov 2009
Harfouche Rania, Hentschel Dirk M, Piecewicz Stephanie, Basu Sudipta, Print Cristin, Eavarone David, Kiziltepe Tanyel, Sasisekharan Ram, Sengupta Shiladitya
Abstract excerpt
BACKGROUND: Therapeutic vasculogenesis is an emerging concept that can potentially be harnessed for the management of ischemic pathologies. The present study elucidates the potential coregulation of vasculogenesis by the heparan sulfate glycosaminoglycan-rich cell-surface glycome and the transcriptome. METHODS AND RESULTS: Differentiation of embryonic stem cells into endothelial cells in an in vitro embryoid body...
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