Article

Trevolver: simulating non-reversible DNA sequence evolution in trinucleotide context on a bifurcating tree

2019-06-18

Abstract excerpt

<h4>Summary</h4> Recent de novo mutation data allow the estimation of non-reversible mutation rates for trinucleotide sequence contexts. However, existing tools for simulating DNA sequence evolution are limited to time-reversible models or do not consider trinucleotide context-dependent rates. As this ability is critical to testing evolutionary scenarios under neutrality, we created Trevolver. Sequence evolution...

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Literature Corpus work: 68166740-f769-5f60-b1ee-033bc232c94b
DOI: 10.1101/672717

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