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Article

A nucleotide substitution model with nearest-neighbour interactions.

Bioinformatics (Oxford, England) - 4 Aug 2004

Lunter Gerton, Hein Jotun

Abstract excerpt

MOTIVATION: It is well known that neighbouring nucleotides in DNA sequences do not mutate independently of each other. In this paper, we introduce a context-dependent substitution model and derive an algorithm to calculate the likelihood of sequences evolving under this model. We use this algorithm to estimate neighbour-dependent substitution rates, as well as rates for dinucleotide substitutions, using a...

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PMID: 15262802
DOI: 10.1093/bioinformatics/bth901

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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