Article

A Proteome-wide, Multi-Omics Analysis Implicates Novel Protein Dysregulation in Post-Traumatic Stress Disorder

2023-05-14

Abstract excerpt

Post-traumatic stress disorder (PTSD) is a common and disabling psychiatric disorder. Here we present findings from the first proteome-wide study of the postmortem PTSD brain. We performed tandem mass spectrometry on large cohort of donors (N = 66) in two prefrontal cortical areas and found differentially expressed proteins and co-expression modules disturbed in PTSD. Integrative analysis pointed to hsa-mir-589 as...

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Literature Corpus work: 68160ebd-e922-5984-8f33-5f791a813017
DOI: 10.1101/2023.05.05.23289589

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