Article
Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits.
Molecular psychiatry - 1 Mar 2022
Pathak Gita A, Singh Kritika, Wendt Frank R, Fleming Tyne W, Overstreet Cassie, Koller Dora, Tylee Daniel S, De Angelis Flavio, Cabrera Mendoza Brenda, Levey Daniel F, Koenen Karestan C, Krystal John H, Pietrzak Robert H, O' Donell Christopher, Gaziano J Michael, Falcone Guido, Stein Murray B, Gelernter Joel, Pasaniuc Bogdan, Mancuso Nicholas, Davis Lea K, Polimanti Renato
Abstract excerpt
Posttraumatic stress disorder (PTSD) is a psychiatric disorder that may arise in response to severe traumatic event and is diagnosed based on three main symptom clusters (reexperiencing, avoidance, and hyperarousal) per the Diagnostic Manual of Mental Disorders (version DSM-IV-TR). In this study, we characterized the biological heterogeneity of PTSD symptom clusters by performing a multi-omics investigation...
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