Article
Brain Proteome-Wide Association Study Identifies Candidate Genes that Regulate Protein Abundance Associated with Post-Traumatic Stress Disorder.
Genes - 27 Jul 2022
Zhang Zhen, Meng Peilin, Zhang Huijie, Jia Yumeng, Wen Yan, Zhang Jingxi, Chen Yujing, Li Chun'e, Pan Chuyu, Cheng Shiqiang, Yang Xuena, Yao Yao, Liu Li, Zhang Feng
Abstract excerpt
Although previous genome-wide association studies (GWASs) on post-traumatic stress disorder (PTSD) have identified multiple risk loci, how these loci confer risk of PTSD remains unclear. Through the FUSION pipeline, we integrated two human brain proteome reference datasets (ROS/MAP and Banner) with the PTSD GWAS dataset, respectively, to conduct a proteome-wide association study (PWAS) analysis. Then two...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.