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Article

Integrating human brain proteomes with genome-wide association data implicates novel proteins in post-traumatic stress disorder.

Molecular psychiatry - 1 Jul 2022

Wingo Thomas S, Gerasimov Ekaterina S, Liu Yue, Duong Duc M, Vattathil Selina M, Lori Adriana, Gockley Jake, Breen Michael S, Maihofer Adam X, Nievergelt Caroline M, Koenen Karestan C, Levey Daniel F, Gelernter Joel, Stein Murray B, Ressler Kerry J, Bennett David A, Levey Allan I, Seyfried Nicholas T, Wingo Aliza P

Abstract excerpt

Genome-wide association studies (GWAS) have identified several risk loci for post-traumatic stress disorder (PTSD); however, how they confer PTSD risk remains unclear. We aimed to identify genes that confer PTSD risk through their effects on brain protein abundance to provide new insights into PTSD pathogenesis. To that end, we integrated human brain proteomes with PTSD GWAS results to perform a proteome-wide...

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Identifiers

PMID: 35449297
DOI: 10.1038/s41380-022-01544-4
PMCID: PMC9233006

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